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Drug exhibits have become more challenging over the years due to an increase in complex synthetic substances with many positional isomer and diastereomer possibilities.
This presentation will introduce solid phase deposition GC-FTIR as a technique which allows for improved specificity and reduced uncertainty in identification of regioisomers, diastereomers, analogs, and other closely related compounds such as fentanyl analogs, pseudoephedrine/ephedrine, phenethylamines, and synthetic cannabinoids.
When compared with mass spectrometry, infrared spectroscopy is able to readily provide detailed chemical information for differential analysis at a higher level of specificity and discrimination that is often unattainable through the use of tandem or high-resolution mass spectrometry techniques.
Coupling the separation power of gas chromatography with the identification ability of infrared spectroscopy affords complementary information based on the retention behavior of the analytes and their spectral fingerprints.
Detailed Learning Objectives:
1. Understand the technology behind solid deposition IR coupled with GC
2. Gain insight into the differences between gas phase IR and solid phase IR
3. Understand the capability to discriminate between isobaric molecules4
This presentation will introduce solid phase deposition GC-FTIR as a technique which allows for improved specificity and reduced uncertainty in identification of regioisomers, diastereomers, analogs, and other closely related compounds such as fentanyl analogs, pseudoephedrine/ephedrine, phenethylamines, and synthetic cannabinoids.
When compared with mass spectrometry, infrared spectroscopy is able to readily provide detailed chemical information for differential analysis at a higher level of specificity and discrimination that is often unattainable through the use of tandem or high-resolution mass spectrometry techniques.
Coupling the separation power of gas chromatography with the identification ability of infrared spectroscopy affords complementary information based on the retention behavior of the analytes and their spectral fingerprints.
Detailed Learning Objectives:
1. Understand the technology behind solid deposition IR coupled with GC
2. Gain insight into the differences between gas phase IR and solid phase IR
3. Understand the capability to discriminate between isobaric molecules4
Date Created: February 3, 2021