The United States Drug Enforcement Administration’s (DEA) Global Uniform Analysis and Reporting of Drug-Related Substances (GUARDS) methodology addresses challenges in identifying synthetic and emerging drugs, improves consistency in forensic reporting, and simultaneously generates more comprehensive information. The DEA’s GUARDS method offers a fast, efficient, cost-effective, and uniform approach to analysis and reporting for the seized drug community.
With the landscape of the illicit drug market evolving to include a rise in synthetic emerging drugs, innovative, comprehensive, and reliable analytical methods are needed to capture the complexity of current polydrug samples fully. Differences in federal, state, and local laws affect how seized drug laboratories analyze and report chemical substances. For example, results from January to December 2023 (CY23) DEA seizures in a New England state show 26% of fentanyl exhibits analyzed contained xylazine. Whereas the National Forensic Laboratory Information System (NFLIS) shows 0% for the same state in CY23. These types of reporting inconsistencies among various agencies impact law enforcement and public health responses to emerging drug threats like xylazine.
As the GUARDS methodology is adopted, establishing the foundation for an enhanced DEA-sponsored Early Warning System, advanced data analytics modeling opportunities will emerge. Additionally, GUARDS supports the TRANQ (Testing, Rapid Analysis, and Narcotic Quality) Research Act of 2023, which requires the National Institute of Standards and Technology (NIST) to support research and other activities related to identifying xylazine, novel synthetic opioids, and other new psychoactive substances.
This workshop will explore the impact inconsistent drug analysis reporting has on public health and public trust. The value and implementation of the GUARDS innovative methodology in over 200 instruments across DEA laboratories will be presented, as well as the efforts of other labs of the U.S. Customs and Border Protection (CBP), Illinois State Police, DuPage County Illinois, and Singapore. Furthermore, new initiatives aimed at increasing the consistency of reported data to NFLIS will be discussed.
Speakers will share the efforts of DEA laboratory chemists to develop, validate, and implement the GUARDS method. Along with CBP, they will discuss experiences and challenges they encountered. Experts from Agilent Technologies and Shimadzu Scientific Instruments will also offer guidance and tools on converting gas chromatography-mass spectrometry (GC-MS) instruments to use hydrogen as the carrier gas. In summary, this workshop aims to provide attendees with an understanding of the history of the GUARDS method, the impact it will have in the forensic community, and resources to support the setup of this methodology in your laboratory.
Detailed Learning Objectives
- Attendees will gain knowledge in how to strengthen seized drug analysis and reporting of drug-related substances.
- Attendees will learn how the GUARDS method was developed and validated at the DEA Special Testing & Research Laboratory.
- Attendees will receive guidance on how to adopt the GUARDS method at their laboratory.
- Attendees will learn from experts how to confidently transition from helium to hydrogen as GC-MS carrier gas and the tools available for laboratories.