NCJ Number
234292
Date Published
April 2011
Length
146 pages
Annotation
The objective of this project was to develop an integrated workflow from laboratory processing to data management for mtDNA sequence data.
Abstract
Mitochondrial DNA analysis has proven to be an invaluable tool for victim identification from mass disasters and missing persons programs to criminal casework (Isenberg, 2004). The University of North Texas Health Science Center (UNTHSC) is primarily funded by the National Institute of Justice (NIJ) for the Missing Persons Program and uses advanced DNA technologies to process unidentified human remains and the family reference samples from biological relatives for both nuclear DNA (nDNA) and mtDNA. Since most missing persons cases rely heavily on mtDNA testing of skeletal remains, mtDNA testing of reference samples is necessary for making family associations. The resulting DNA profiles are uploaded to the Missing Persons Index database. In this database, mtDNA and nDNA profiles from the unidentified remains can be searched against the biological family reference profiles and associations are recommended through kinship analysis testing. There are several hundred thousand missing persons cases reported each year and there are more than 14,000 unidentified human skeletal remains retained in medical examiners' and coroners' offices nationwide (Rhonda K. Roby et al., 2007). These numbers alone demonstrate the throughput requirements needed for DNA processing.
Date Published: April 1, 2011
Downloads
Similar Publications
- Criticality of Spray Solvent Choice on the Performance of Next Generation, Spray-Based Ambient Mass Spectrometric Ionization Sources: A Case Study Based on Synthetic Cannabinoid Forensic Evidence
- Harmonizing the Forensic Nomenclature for STR Loci D6S474 and DYS612
- Postmortem CT Scans Supplement and Replace Full Autopsies