Since the human face is complex and multipartite, and characterization of its genetic architecture remains challenging, the current study used a multivariate genome-wide association study meta-analysis of 8,246 European individuals.
The study identified 203 genome-wide-significant signals (120 also study-wide significant) associated with normal-range facial variation. Follow-up analyses indicated that the regions surrounding these signals were enriched for enhancer activity in cranial neural crest cells and craniofacial tissues, with several regions harboring multiple signals with associations to different facial phenotypes. There was also evidence for potential coordinated actions of variants. In summary, the analyses provide insights on how complex morphological traits are shaped by both individual and coordinated genetic actions. (publisher abstract modified)
Downloads
Similar Publications
- Detection of Ignitable Liquid Residues in Fire Debris by Using Direct Analysis in RealTime Mass Spectrometry (DART-MS)
- Raman Spectroscopy and Chemometrics for Forensic Bloodstain Analysis: Species Differentiation, Donor Age Estimation, and Dating of Bloodstains
- Elucidation of the Effect of Solar Light on the Near-Infrared Excitation Raman Spectroscopy-Based Analysis of Fabric Dyes