NCJ Number
304485
Journal
Analytical and Bioanalytical Chemistry Volume: 393 Dated: 2009 Pages: 1135–1141
Date Published
2009
Length
7 pages
Annotation
This paper describes the development and application of a pH-sensitive plasmonics-active fiber-optic nanoprobe suitable for intracellular bioanalysis in single living human cells using surface-enhanced Raman scattering (SERS) detection.
Abstract
The effectiveness and usefulness of SERS-based fiber-optic nanoprobes are illustrated by measurements of intracellular pH in HMEC-15/hTERT immortalized “normal” human mammary epithelial cells and PC-3 human prostate cancer cells. The results indicate that fiber-optic nanoprobe insertion and interrogation provide a sensitive and selective means to monitor cellular microenvironments at the single cell level. (Publisher Abstract)
Date Published: January 1, 2009