DEVELOPMENT OF DNA PROFILING DATABASE IN AN HAE III BASED RFLP SYSTEM FOR CHINESE, MALAYS, AND INDIANS IN SINGAPORE

• NCJ Number: 145757
• Journal: Journal of Forensic Sciences Volume: 38 Issue: 4 Dated: (July 1993) Pages: 874-884
• Author(s): S T Chow; W F Tan; K H Yap; T L Ng
• Date Published: 1993
• Length: 11 pages
• Publication Format: Article
• Publication Type: Report (Technical)
• Language: English
• Country: United States of America

Annotation

Deoxyribonucleic acid (DNA) restriction fragment length polymorphism profiles were obtained for blood specimens from three population groups in Singapore to facilitate the genetic characterization of evidentiary materials.

Abstract

Whole blood samples from unrelated Chinese, Malays, and Indians were obtained through the Singapore Blood Transfusion Service. Population databases were collected from Hae III digested, high molecular weight DNA hybridized with four variable number of tandem repeats loci (D2S44, D10S28, D4S139, and D157). Data were analyzed statistically using the fixed bin system. A comparison of the ratio of bin frequencies for the three population groups in Singapore with published data on whites, blacks, and Hispanics showed that the alleleic distribution for the four loci was not seriously different among the six groups. The findings have important implications relative to the statistical significance of forensic DNA applications. 16 references, 7 tables, and 4 figures