DISTRIBUTION OF MORPHINE AND RELATED COMPOUNDS IN HUMAN TISSUES AND BIOLOGICAL FLUIDS USING RADIOIMMUNOASSAY TECHNIQUES

• NCJ Number: 13574
• Journal: Journal of Forensic Sciences Volume: 19 Issue: 2 Dated: (APRIL 1974) Pages: 307-312
• Author(s): R J COUMBIS; B KAUL
• Date Published: 1974
• Length: 6 pages
• Corporate Author: American Soc for Testing and Materials
• Publication Format: Article
• Language: English
• Country: United States of America
• Note: *This document is currently unavailable from NCJRS.

Annotation

DESCRIPTION OF A RAPID, SIMPLE, RELIABLE, AND SENSITIVE PROCEDURE FOR THE DETECTION OF NARCOTICS IN AUTOPSY MATERIALS.

Abstract

RADIOIMMUNOASSAY PROVIDES A DIRECT ASSAY METHOD FOR BIOLOGICAL FLUIDS AND A SIMPLE SALINE EXTRACTION WHEN TISSUES ARE INVESTIGATED FOR NARCOTICS AND RELATED DRUGS. IN THIS STUDY IT WAS NOTED THAT BILE VISCOSITY AND BLOOD HEMOLYSIS RESULTED IN HIGHER MORPHINE LEVELS. THIS INTERFERENCE CAN BE ELIMINATED IF PROPER DILUTIONS ARE MADE. ALTHOUGH RADIOIMMUNOASSAY LACKS SPECIFICITY, IT DOES PROVIDE SENSITIVITY. MORPHINE CAN BE DETECTED IN PICOGRAMIC LEVELS. ITS APPLICATION IN MEDICOLEGAL CASES WITH WELL-ESTABLISHED HISTORIES OF NARCOTIC ADDICTION WILL BE INVALUABLE. (AUTHOR ABSTRACT)