NCJ Number
174229
Journal
Journal of Forensic Sciences Volume: 41 Issue: 4 Dated: July 1996 Pages: 591-602
Date Published
1996
Length
12 pages
Annotation
This study describes variation in the mitochondrial DNA (mtDNA) control region as detected by sequence-specific oligonucleotide (SSO) probes for 993 individuals in 11 ethnic Asian populations.
Abstract
Estimates of diversity for mtDNA types exceeded 0.94 in all populations, and 53 percent of the 255 types that were observed occurred only once. Of 96 shared types, 4 occurred at frequencies greater than 10 percent but less than 17 percent in any one population. There was statistically significant heterogeneity among these 11 populations; however, an analysis of variance that incorporated genetic distances between types showed that at least 95 percent of the variation present in the total sample was attributable to within-population diversity, and only 5 percent was due to between-population differences. Overall, heterogeneity with respect to mtDNA SSO types was grossly correlated with geographic distance between populations; the most extreme heterogeneity was observed between populations from East Asia and populations from West Asia. Regarding population genetics, the control region of mtDNA exhibited satisfactory qualities as a DNA typing locus. 6 tables, 5 figures, and 32 references