NCJ Number
130228
Journal
Journal of Forensic Sciences Volume: 36 Issue: 3 Dated: (May 1991) Pages: 930-935
Date Published
1991
Length
6 pages
Annotation
The authors describe a case of fatal acetaminophen overdose which occurred in a 16-year-old female. Her serum acetamoniphen concentration 11.5 h postingestion was 154 mg/L.
Abstract
Antidotal therapy was unsuccessful, and after nine days she died. Autopsy findings included centrilobular zonal liver necrosis, acute proximal renal tubular necrosis, and diffuse alveolar pulmonary damage. Her heart was transplanted into a young woman with congenital heart disease. The recipient expired 14 days after the transplant as a result of sepsis complicating bowel ischemia. The transplanted heart showed extensive subendocardial myocyte necrosis related to acetaminophen toxicity and not rejection. 4 figures and 17 references (Author abstract)