Identification and Quantitation of Pharmaceutical Preparations by Nuclear Magnetic Resonance Spectroscopy

• NCJ Number: 128902
• Journal: Journal of Forensic Sciences Volume: 36 Issue: 2 Dated: (March 1991) Pages: 358-365
• Author(s): S A Angelos; T J Janovsky; J K Raney
• Date Published: 1991
• Length: 8 pages
• Publication Format: Article
• Publication Type: Survey
• Language: English
• Country: United States of America

Annotation

The identification and quantitation of pharmaceutical preparations is often the most time-consuming analysis performed in the forensic science laboratory. Because of their hygroscopic and polymorphic properties, matching infrared spectra are frequently difficult to obtain.

Abstract

Moreover, many of these compounds also fragment in such a manner that their mass spectra are difficult to interpret. Nuclear magnetic resonance offers an attractive alternative analysis since it avoids these problems and allows simultaneous identification and quantitation of dosage forms. Typical procedures are described for pharmaceutical forms of barbituates, phenethylamines, quinazolones, benzodiazepines, and ethchorvynol. This method has been successfully used and in most cases does not require a preliminary separation of the pharmaceutical preparation's components. 3 tables and 33 references (Author abstract)