Isotopic Analogue as the Internal Standard for Quantitative Determination of Benzoylecgonine: Concerns With Isotopic Purity and Concentration Level

• NCJ Number: 121312
• Journal: Journal of Forensic Sciences Volume: 34 Issue: 4 Dated: (July 1989) Pages: 986-990
• Author(s): R H Liu; L D Baugh; E E Allen; S C Salud; J G Fentress; H Chadha; A S Walia
• Date Published: 1989
• Length: 5 pages
• Publication Format: Article
• Publication Type: Research (Applied/Empirical)
• Language: English
• Country: United States of America

Annotation

Empirical data is used to demonstrate the observation and quantification of benzoylecgonine in negative test samples when high concentrations of deuterated benzoylecgonine are used as the internal standard in the assay process.

Abstract

On the quantitative determination of true positive samples, inaccuracy introduced by the isotopic impurity of the internal standard is calculated as a function of the impurity and the concentration levels of the internal standard used. (Author abstract)