NCJ Number
175186
Journal
American Journal on Addictions Volume: 6 Issue: 4 Dated: Fall 1997 Pages: 339-349
Date Published
1997
Length
11 pages
Annotation
A meta-analysis focused on the 14 reported randomized, controlled trials that compared methadone to L-alpha-acetylmethadol (LAAM) to assess the relative effectiveness of these two therapies in the treatment of heroin addiction.
Abstract
The studies were located through a search of MEDLINE and a review of bibliographies of retrieved articles and pertinent review articles, The search spanned 1966-96. All studies were conducted in standard outpatient opiate addiction treatment clinics. Most participants were men from lower socioeconomic strata. Results revealed a statistically significant risk difference that favored methadone for retention in treatment and for discontinuation of treatment because of side effects. The risk difference for illicit drug use favored LAAM, but the difference was not significant. A small treatment difference in favor of methadone was also noted. Findings indicated that LAAM is a relatively effective alternative in the treatment of opiate addiction, given its potential practical and operational benefits in comparison to methadone in certain situations. Tables and 33 references (Author abstract modified)