Mild Intellectual Disability Associated with a Progeny of Father-Daughter Incest: Genetic and Environmental Considerations

• NCJ Number: 231431
• Journal: Journal of Child Sexual Abuse Volume: 19 Issue: 3 Dated: May-June 2010 Pages: 337-344
• Author(s): Francois Ansermet; James Lespinasse; Stefania Gimelli; Frederique Bena; Ariane Paoloni-Giacobino
• Date Published: May 2010
• Length: 8 pages
• Grant Number(s): FNS 3100A0-116021
• Sponsoring Agency: Swiss National Science Foundation (SNSF)
• Publication Format: Article
• Publication Type: Research (Applied/Empirical)
• Language: English
• Country: United States of America

Annotation

This article examines the genetic and environmental factors that may occur in children resulting from father-daughter sexual abuse.

Abstract

The article reports the case of a 34-year-old female resulting from a father-daughter sexual abuse and presenting a phenotype of mild intellectual disability with minor dysmorphic features. Karyotyping showed a normal 46, XX constitution. Array-based comparative genomic hybridization (array-CGH) revealed a heterozygote 320kb 6p22.3 microdeletion in the proband, encompassing only one known gene, and therefore unlikely to be the cause of the phenotype. However, the role of other genetic factors, such as a recessive condition, could not be ruled out as a putative cause for the phenotype. On the other hand, the role played by a heavily detrimental familial situation on the development and outcome, and possibly leading or contributing to a mild intellectual disability, should be taken into account. Figure and references (Published Abstract)