Mutations of Microsatellite Autosomal Loci in Paternity Investigations of the Southern Poland Population

• NCJ Number: 246392
• Journal: Forensic Science International: Genetics Volume: 7 Issue: 3 Dated: May 2013 Pages: 389-391
• Author(s): Marta Wojtas; Danuta Piniewska; Nina Polañska; Agnieszka Stawowiak; Marek Sanak
• Date Published: May 2013
• Length: 3 pages
• Publication Format: Article
• Publication Type: Report (Study/Research)
• Language: English
• Country: United States of America

Annotation

In this study, germline mutations were analyzed for 26,040 parent-child allelic transfers among subjects referred to paternity testing and originating from the Slavonic population of the Southern Poland.

Abstract

Mutation rates were estimated for 15 autosomal microsatellite loci: D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818 and FGA. There were 35 mutation events observed at 11 from 15 analyzed loci. No mutations were found at TH01, D2S1338, D19S433 and TPOX loci. The mutation rate estimate was 0.0019 [0.0012-0.0028 95 percent CI] for paternal and 0.0004 [0.0002-0.0009] for maternal meiosis, while 25% mutations remained unassigned. The locus-specific mutation rate ranged from 0.0000 [0.0000-0.0014] to 0.0046 [0.0022-0.0087]. Mutations observed in male germlines were more frequent than in female germlines. (Published Abstract)