Population Data on the Thirteen CODIS Core Short Tandem Repeat Loci in African Americans, U.S. Caucasians, Hispanics, Bahamians, Jamaicans, and Trinidadians

• NCJ Number: 183901
• Journal: Journal of Forensic Sciences Volume: 44 Issue: 6 Dated: November 1999 Pages: 1277-1286
• Author(s): Bruce Budowle Ph.D.; Tamyra R. Moretti Ph.D.; Anne L. Baumstark B.S.; Debra A. Defenbaugh B.S.; Kathleen M. Keys B.S.
• Date Published: November 1999
• Length: 10 pages
• Publication Format: Article
• Publication Type: Report (Study/Research)
• Language: English
• Country: United States of America

Annotation

This study determined allele distributions for 13 tetrameric short tandem repeat (STR) loci in African-American, U.S. Caucasian, Hispanic, Bahamian, Jamaican, and Trinidadian sample populations.

Abstract

The 13 loci were CSF1PO, FGA, TH01, TPOX, VWA, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, and D21S11. Regarding materials and methods, this article describes sample preparation, STR amplification, STR typing of PowerPlex-amplified samples, STR typing of Profiler Plus and COfiler amplified samples, and statistical analysis. The study found little evidence for departures from Hardy-Weinberg expectations (HWE) in any of the populations. Based on the exact test, the loci that departed significantly from HWE are D21S11 (p = 0.011, Bahamians); CSF1PO (p = 0.014, Trinidadians); TPOX (p = 0.011, Jamaicans and p = 0.035, U.S. Caucasians); and D16S539 (p = 0.043, Bahamians). After using the Bonferroni correction for the number of loci analyzed (i.e., 13 loci per database), these observations are not likely to be significant. There is little evidence for association of alleles between the loci in these databases. The allelic frequency data are similar to other comparable data within the same major population group. 2 tables and 27 references